Request PDF on ResearchGate | DemTect | DemTect is a cognitive screening instrument, first published in , which was designed to be sensitive to the early. PDF | Many cognitive screening instruments have been developed and pay regard to some critical aspects are described: the DemTect. Background: We have developed a new, highly sensitive psychometric screening test (DemTect), especially designed to detect mild cognitive impairment (MCI).
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Kessler, J.; Kalbe, E.; Calabrese, P.; Smith, B.; Passmore, P.; Bullock, R., DemTect Final english version of a new cognitive screening test for mild cognitive . P DemTect: Final English version of a new cognitive screening test for mild cognitive impairment and Download PDF . DemTect: cognitive impairment. SIR—The DemTect Scale is a brief screening test for dementia comprising five short subtests (word list repetition, number transcoding, semantic word fluency.
Cognitive Screening Instruments
One of the most important and frequently used clinical dementia screening devices is the DemTect Kalbe et al. In order to link dementia syndromes to underlying impairments in neural networks, investigation of subtests addressing specific cognitive domains is necessary. The neural networks affected by neurodegenerative diseases, especially Alzheimer's disease AD Barnes et al. Underlying different etiologies and pathomechanisms Finder, ; Rabinovici and Miller, , AD and FTLD have been related to specific metabolic and atrophic brain changes.
Accordingly, the correction for partial volume effects is a state-of-the-art step in preprocessing of FDG-PET imaging data see also Baete et al.
Recently, PVE-correction has been successfully applied when comparing atrophy and hypometabolism in AD Chetelat et al. Although one study has investigated glucose metabolism and amyloid plaque density in subjects with AD and semantic dementia Drzezga et al.
Firstly, our study aimed at investigating differences in FDG metabolism and gray matter atrophy with regard to their localization, as well as their extent in subjects suffering from AD or FTLD, using data corrected for PVE.
Second, we intended to contribute to the external validation of the DemTect as a diagnostic tool capable of detecting cognitive deficits and linking them to morphological and glucose metabolic changes in the brain. Microarrays were performed as described earlier . The SPSS 9.
Among these were the alpha2C-adreuoreceptor gene, known to regulate blood pressure, aud learuing, the defeusiu, histocompability complex euhaucer-binding protein, carboxypeptidase M, Fc fragment of IgE knowu to be involved in cellular aud humoral immuue respouses.
Real-time QRT-PCR analysis was perfonned in order to coufinn the expression chauges in AD lymphocytes aud it could detect downregulation of defeusiu aud alpha2C-adreuoceptor genes, while other genes seemed unaltered in their expression, iucludiug hsp90, CET aud apoB Conclusion: The altered expression profile of these genes might be comlected with the previously reported AD specific lymphocyte abuonnalities.
It remaius to be elucidated however, how these genes are related to the pathomechauism of dementia aud whether the geue expression differences of AD lymphocytes reflect disease trait or stage processes. Aging, USA, ; Kalbe2, P.
Calabrese3, B. Smith4, P Passmore5, R. The test: It consists of A word list: After pilot study it was found that a psychomepatients with dementia in 5 subtests.
Degenerative and 10 items aud two trials is adequate to assess verbal memory in dementia. The items were easy to imagine, comparable in syllable length aud phonological difference.
Thus the test covers a broad rauge of cognitive abilities.
A Practical Approach
It is short S minutes , easy to haudle aud also provides age aud education corrected scoring. Patients aud results: For the uormatiou of the English DemTect version, a total of control subjects control group CG meau age We per- versions of the five original DemTect subtests word list learning, number formed correlational and stepwise linear regression analyses to explore the transcoding, semantic verbal fluency, digit span reverse, and word list de- association between subtests of the ARCS and tests of corresponding cogni- layed recall were designed.
The equivalence of the new and original sub- tive domains from the formal neuropsychological battery, before and after tests were analyzed in 80 healthy control subjects age: Results: The sample 9. DemTect and DemTect B were assessed in randomized order.
Re- pairment and 28 without cognitive impairment. Mean patient AES score was sults: There were no significant differences between the corresponding sub- Increasing symptoms of apathy or depression had no effect on these scores were calculated for this subtest.
For all other subtests, the transforma- associations with only one exception.Among these were the alpha2C-adreuoreceptor gene, known to regulate blood pressure, aud learuing, the defeusiu, histocompability complex euhaucer-binding protein, carboxypeptidase M, Fc fragment of IgE knowu to be involved in cellular aud humoral immuue respouses.
Preliminary but positive results also exist for patients with Parkinson's disease and dementia.
Methods: The sample was derived from the general practitioner GP -based, cluster-randomized controlled intervention trial DelpHi-MV Dementia: life- and person-centered help in Mecklenburg-Western Pomerania. Re- pairment and 28 without cognitive impairment. The items were easy to imagine, comparable in syllable length aud phonological difference. Results: Of the patients who completed the l-year doubleblind study aud enrolled iuto the 2-year exteusiou study, 81 received coutiuuous douepezil treatment for 3 years aud 76 had a delayed treatment start, ie received placebo for oue year followed by douepezil for 2 years.
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